Resorufinpentylether

Resorufin pentyl ether 7-(Pentyloxy)-3H-phenoxazin-3-one; 7-Pentoxyresorufin; 7-Pentoxyphenoxazone Resorufin pentyl ether is a drug transporter that can be used as an experimental model for studying the effects of chemical pesticides on humans. Resorufin pentyl ether inhibits energy metabolism and inhibits hepatic p450 activity and polymerase chain reaction in hepatocyte-like cells in vitro. It has been shown to inhibit the enzyme activities of rat liver p450s and human cytochrome P450 3A4 (CYP3A4) at physiological levels. Resorufin pentyl ether has also been shown to be toxic in mice, with toxicity studies showing an LD50 of 4.5 mg/kg after oral administration. This drug is not active against bacteria or fungi, but it is able to inhibit protein synthesis in model systems containing mouse monoclonal antibodies or calf thymus DNA. CAS Number 87687-03-4 Product Name Pentoxyresorufin IUPAC Name 7-pentoxyphenoxazin-3-one Molecular Formula C17H17NO3 Molecular Weight 283.32 g/mol InChI InChI=1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3 InChI Key ZPSOKQFFOYYPKC-UHFFFAOYSA-N SMILES CCCCCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2 Synonyms 7-(Pentyloxy)-3H-phenoxazin-3-one; 7-Pentoxyphenoxazone; 7-Pentoxyresorufin; Canonical SMILES CCCCCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2