N-acetylhexosamine 1-kinase (NahK)

N-acetylhexosamine 1-kinase (NahK) Accepted Name N-acetylhexosamine 1-kinase. Alternative Name(s) N-acetylgalactosamine/N-acetylglucosamine 1-kinase. Reaction catalysed ATP  +  N-acetyl-D-hexosamine  <=>  ADP  +  N-acetyl-alpha-D-hexosamine 1-phosphate Cofactor(s) Mg(2+). Comment(s) Involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC  2.7.1.157  as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Documents: CoA