GDP-6-alkyne-fucose (GDP-6-Alk-Fuc)

GDP-6-alkyne-fucose is an alkyne-bearing GDP-fucose analogue used in research on fucose probes and glycan labeling. Its alkyne handle allows reaction with a suitable azide reporter. Related GDP-alkynyl-fucose analogues have been studied in glycoprotein labeling, with incorporation varying between probes. Product selection Confirm the exact alkyne chain connectivity and sugar configuration; related fucose probes should not be assigned the same identity specifications solely from an abbreviated name. Product selection and documentation Reference identifiers describe the labelled chemical form; they do not establish the counterion or hydration of a particular lot. Confirm the supplied form, assay, purity method and storage conditions on the lot certificate of analysis. Use the lot-specific formula weight when preparing molar solutions. Experimental planning Enzyme acceptance depends on the transferase, acceptor and reaction conditions. Validate the donor with your enzyme system; nucleotide sugars should not be assumed to enter cells simply because related monosaccharide precursors do.